Glycoprotein VI (platelet), also known as GPVI, is a
glycoprotein receptor for
collagen which is expressed in
platelets. In humans, glycoprotein VI is encoded by the ''GPVI''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
GPVI was first cloned in 2000 by several groups including that of
Martine Jandrot-Perrus from INSERM.
Function
Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the
endothelial
The endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel ...
lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most
thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting
platelet plug
The platelet plug, also known as the hemostatic plug or platelet thrombus, is an aggregation of platelets formed during early stages of hemostasis in response to one or more injuries to blood vessel walls. After platelets are recruited and begi ...
is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of
atherosclerotic plaque
An atheroma, or atheromatous plaque, is an abnormal and reversible accumulation of material in the inner layer of an arterial wall.
The material consists of mostly macrophage cells, or debris, containing lipids, calcium and a variable amount ...
s is a major stimulus of thrombus formation associated with myocardial infarction or stroke.
Complete or partial deficiency of GPVI in humans is a rare condition presenting as a mild bleeding disorder.
Interactions
GPVI has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
LYN.
See also
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collagen receptor
Collagen receptors are membrane proteins that bind the extracellular matrix protein collagen, the most abundant protein in mammals. They control mainly cell proliferation, migration and adhesion, coagulation cascade activation and they affect ECM s ...
References
Further reading
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External links
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{{Coagulation